Amniotic fluid embolism is a rare but potentially lethal condition. Because of the rarity of this condition, most physicians and institutions have limited experience with the management of amniotic fluid embolism. The typical presentation of AFE includes a triad: sudden hypoxia hypotension, and coagulopathy. In this podcast, we will cover the latest data from the SMFM, ACOG, and AHA on this terrifying condition.