Researchers estimate that approximately 10.2 million Americans have osteoporosis, and an additional 43 million have low bone density. Equally stark are the ramifications of these numbers. About 1 out of every 2 Caucasian women will experience an osteoporosis-related fracture at some point in their lifetime. In April 2019, the FDA approved a new dual action medication for osteoporosis therapy in postmenopausal women considered at high risk of fracture. This new medication is Evenity. In this episode, we will review the pathophysiology, diagnosis of, and treatment updates osteoporosis.