In the decades after the founding of Charleston in 1670, more than a dozen tribes of indigenous people across the Lowcountry interacted with the growing population of White settlers and enslaved Africans. Disease, warfare, and displacement gradually reduced their numbers, however, and the first people of the Lowcountry were virtually extinct by the middle of the eighteenth century. https://www.ccpl.org/charleston-time-machine/first-people-south-carolina-lowcountry