In 1932 a governmental agency called the Public Health Service began working with the Tuskegee Institute to study syphilis in black men. In 1947, when penicillin was discovered as the illness cure, participants in the study were denied treatment in “order to study the natural outcome of disease”. In the early 1970s, the “study” was finally deemed unethical and was stopped. As syphilis cases continue to rise in the US, we must not forget the principles of ethical scientific discovery and not forget those who participated in a study which violated all currently accepted ethical standards.