Parvovirus B 19 is a single-stranded DNA virus that causes the childhood exanthem known as fifth disease. The risk of maternal Parvo B19 infection varies with the level of exposure to the infected individual. Parvo B19 may cause asymptomatic fetal infection or may result in fetal loss, hydrops fetalis, or stillbirth. Currently, the ACOG does not recommend universal screening of Parvo B19 immunity. In this session, we will review the ACOG data on maternal and fetal Parvo B19 infection.