From May 1918 to October 1919, New Orleans, Louisiana had a serial killer who was dubbed The Axeman. He (or she) earned this moniker when they would attack Italian immigrants and Italian-Americans, using their own axe in most cases. This case has never been solved.
Sources for this episode:
Wikipedia - Axeman of New Orleans
Wikipedia - New Orleans
Smithsonian Magazine - The Axeman of New Orleans Preyed on Italian Immigrants
New Orleans Ghosts - The Axeman Of New Orleans
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