He was born in Rome, and as a young man was chosen by the Emperor Constantine to assist in the foundation of his new capital at Byzantium. An outbreak of leprosy in the new City became so severe that the Emperor ordered that all lepers, whatever their rank, be driven from the city or drowned in the sea. Zoticus, moved by compassion for these people, went to the Emperor and asked him for a large amount of gold to buy gems and pearls to enhance the glory of the city, 'For, as Your Majesty knows, I am well-qualified in this field.' The Saint then used the gold to ransom all those being led into exile or to drowning, and to establish for them a camp on the hill of Olivet on the opposite shore of the Bosphorus. There he brought the sick and provided for their care.
In 337 Constantius, an Arian heretic, took the throne upon the death of his father. Some of Zoticus' enemies at court, seeing an opportunity, denounced Zoticus to the new Emperor, saying that he not only held subversive views,