Nipple discharge is a common breast symptom. Keys and clues to stratify patients as either low risk or high-risk include: the patient’s age, unilateral or bilateral discharge, single duct or multi duct, whether a mass is also present in the breast, and the color of the discharge. Most nipple discharge thankfully is benign, but some require more attention. In this session, we will review the ACOG practice bulletin number 164 regarding nipple discharge.