Infertility. It’s real. It affects 10-15% of couples in the US. After a thorough investigation, 30% of couples will be left without an identifiable cause for their infertility. This has been termed unexplained infertility. While traditionally this may have been considered a reassuring result, new data is raising the yellow flag of caution in these patients. Research has now established the link between infertility and some potential future negative health outcomes. As “next generation“ genetic tests become more integrated into clinical practice, new data (released ahead of print on March 16, 2023 in the New England Journal of Medicine) has revealed some life-changing realities for couples struggling with unexplained infertility. In this episode, we will highlight the advances in genetic medicine and summarize the key findings of this eye-opening new publication.