Welcome to Ask Stago, the weekly podcast for Hemostasis laboratory professionals. This week, with our expert Frédéric Brutto, product line manager, Cécile Hourquet and Audrey Carlo will question HIL interferences and how the coagulation laboratory can handle them.  

Sources: 

• Lippi G et al., Interference of blood cell lysis on routine coagulation testing. Arch Pathol Lab Med. 2006;130(2):181-4 
• Woolley A et al., Effects of haemolysis, icterus and lipaemia on coagulation tests as performed on Stago STA-Compact-Max analyser. Int J Lab Hematol. 2016; 38(4): 375-88 
• Plebani M, Quality Indicators to Detect Pre-Analytical Errors in Laboratory Testing, Clin Biochem Rev 2012; 3: 85-88. 
• Salvagno GL et al, Prevalence and type of pre-analytical problems for inpatients samples in coagulation laboratory, J Eval Clin Pract. 2008 ;14(2):351-3. 
• CLSI Hemolysis, Icterus, and Lipemia/Turbidity Indices as Indicators of Interference in Clinical Laboratory Analysis; Approved Guideline. CLSI document C56-A. Wayne, PA: Clinical and Laboratory Standards Institute; 2012 
• CLSI Collection, Transport and Processing of Blood Specimens for Testing Plasma-based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline – Fifth Edition. CLSI Document H21-A5; Wayne, PA: Clinical and Laboratory Standards Institute; 2008

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Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.