He was born to a noble family in Alexandria. For a short time he taught rhetoric in Pelusium in Egypt; but soon his love for the things of God led him to flee to the Desert as a solitary. After a year of ascetical life, he returned to Pelusium, where he was ordained to the priesthood. After a few years he retired to a monastery where he spent the rest of his life, eventually becoming Abbot. From the monastery he wrote thousands of epistles full of divine grace and wisdom; of these more than two thousand still survive.
  Saint Isidore was a student and devout disciple of St John Chrysostom, as he knew him through his writings. When St Cyril became Patriarch of Alexandria, he refused to commemorate St John in the diptychs during the Divine Liturgy. Saint Isidore wrote him a strong letter reminding him not to heed the rumors, prejudices or threats of men, and St Cyril was persuaded to restore commemoration of the Archbishop of Constantinople, and later became a strong advocate of the vene