1) NMO spectrum and MS brain lesion and 2) Topic of the month: Stroke trials. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Mark Keegan interviews Dr. Lucy Matthews about her paper on seropositive NMO spectrum disorder and MS brain lesion distribution. Dr. Adam Numis is reading our e-Pearl of the week about intravascular B-cell lymphoma. In the next part of the podcast Dr. Brett Kissela interviews Dr. Joseph Broderick about IMS III trial. All the participants have disclosures.Dr. Keegan serves as Chief Editor for eMedicine; is a consultant for Bionest and Novartis. Dr. Matthews receives research support from UK Medical Research Council and is funded by the Clinical Research Training Fellow ship.Dr. Numis serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Kissela serves on scientific advisory board for Allergan, Inc.; has received funding for travel and speaker honoraria from Allergan, Inc.; has received research support from the NIH, will receive compensation from Reata Pharmaceuticals, Inc. for serving on the Event Adjudication Committee for the BEACON study, which they are sponsoring. and provides medico-legal reviews.Dr. Broderick has served as a consultant for PhotoThera-DSMB for NEST III study and Genentech, Inc.; receives funding for travel to NIH study section and NIH-sponsored meetings, TST meeting and national meeting by Covidien and RISS Summit by Genentech and as part as invited Visiting Professor; has received research support from Boehringer Ingelheim, Concentric, EKOS, Genentech, Inc, Johnson & Johnson, Novo Nordisk, Schering-Plough Corp, Merck, and the NIH as part of NINDS funded clinical trials.