Few startup founders follow a path to success like Daphne Koller, a polymath whose academic career in machine learning, computer vision, and computational biology make her a force far beyond the business arena. Koller left her academic career at Stanford in 2012 to co-found Coursera, the world’s largest platform for massive open online courses (MOOCs). After building the company into a global phenomenon she left Coursera in 2016 to become chief computing officer at Calico, and in 2018 she founded insitro, a drug discovery startup. In this episode, Mike Maples, Jr. of Floodgate talks with Koller about the origins of Coursera and the challenges the company faced in its early days, as well as its lasting impact for learners worldwide. She also discusses what she sees in the future for insitro and why she believes so strongly in machine learning-driven drug discovery and development.  Check out the Pattern Breakers Blog at patternbreakers.substack.com for even more Pattern Breaking content from Mike.  Mike's book Pattern Breakers is available now wherever you buy books.Follow Mike on X!