In this episode of The Human Upgrade, Dr. Manoj Doss, a neuroscientist at the University of Texas at Austin Dell Medical School, explores the fascinating intersection of psychedelics, memory, and cognitive enhancement. Drawing from his extensive research, Dr. Doss dives into how psychoactive substances like THC, ketamine, and psychedelics can alter memory formation, consolidation, and retrieval. He challenges the conventional understanding of memory by revealing how these substances might disrupt traditional memory processes while potentially opening new pathways for learning and cognition. 

You'll discover how different drugs impact your brain's ability to encode and recall information, the surprising effects of psychedelics on semantic and episodic memory, and the role of the hippocampus in shaping our personal narratives. Dr. Doss also delves into the potential benefits and risks of cognitive enhancers like nicotine and modafinil, offering insights into their effects on memory and brain function. 

Dr. Doss provides a nuanced perspective on the malleability of memory, the ethical implications of memory manipulation, and the complex relationship between trauma, memory, and psychedelics. This episode is essential for anyone interested in the cutting-edge science of memory, the therapeutic potential of psychedelics, and the quest to enhance cognitive performance. 

Timestamps: 

• 00:00:01 — Opening 
• 00:01:39 — Introduction to Dr. Manoj Doss 
• 00:03:20 — The Impact of Psychedelics on Memory 
• 00:05:50 — The Predictive Processing Framework and Mind Models 
• 00:13:22 — Alcohol and Retrograde Facilitation: Enhancing Memory Post-Study 
• 00:19:00 — Differences Between Episodic and Semantic Memory 
• 00:22:57 — The Role of the Hippocampus in Memory Formation 
• 00:32:35 — Exercise, BDNF, and Memory Enhancement 
• 00:42:29 — The Complex Relationship Between Psychedelics and Neurogenesis 
• 00:52:16 — The Fallibility of Memory and False Memory Formation 
• 01:09:04 — The Influence of Nicotine, Modafinil, and Other Cognitive Enhancers 
• 01:30:34 — Closing Remarks 

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Resources: 

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