Fibrillar amyloid-beta and Bioethics-beneficence. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Brandy Matthews interviews Dr. Susan Resnick about her paper on cognitive decline is associated with fibrillar amyloid-beta. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about the Eastchester clapping sign. In the next part of the podcast Dr. Ted Burns interviews Dr. Dan Larriviere for our Lesson of the Week about principles of bioethics-beneficence. The participants had nothing to disclose except Drs. Resnick, Matthews, Larriviere, and Burns.Dr. Resnick serves as Action Editor for Brain and Cognition; and received research support from the NIH/NIA Intramural Research Program.Dr. Matthews received honoraria for attending the AAN Annual Meeting in Seattle in 2009; and received research support from Indiana Alzheimer Disease Center, and NIA funded program from 2008 to present.Dr. Larriviere has received honoraria for serving on the American Association for the Advancement of Science Faculty; and has received an unrestricted educational grant from Allergan, Inc.Dr. Burns receives a stipend as Podcast Editor for Neurology®; and performs EMG studies in his neuromuscular practice (30% effort).