This Podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Interim Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. David Geldmacher interview Drs. Clifford Jack and Prashanthi Vemuri about their papers on MRI and CSF biomarkers in normal, MCI and AD. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about electroencephalography in Moyamoya disease. The next part of the podcast is Dr. Beau Bruce interviews Dr. Dan Moore for our LOTW. In concluding, there is a brief statement where to find other up-to date patient information and current Patient Page. The participants had nothing to disclosure except Dr. Jack is an investigator in clinical trials sponsored by Pfizer, consults for Elan, and is funded by the NIH grant R01-AG11378 and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation.