In this episode, Drs Trexler and Helms are joined by Dr. Eduardo De Souza to discuss the complexities and misconceptions surrounding high volume training in the context of hypertrophy research. He shares insights from his extensive research background, emphasizing the importance of understanding participant experiences and the nuances of training volume. The conversation also touches on the challenges of research methodology, the need for improved reporting standards, and the future directions of exercise science research. Time stamps: 0:00 Introducing Dr Eduardo De Souza and some housekeeping https://sportsnutritionassociation.com/sna-annual-2025-conference/ 4:23 Eduardo's background and work in high volume training research Scarpelli 2022 Muscle Hypertrophy Response Is Affected by Previous Resistance Training Volume in Trained Individuals https://pubmed.ncbi.nlm.nih.gov/32108724/ Enes 2024 Effects of Different Weekly Set Progressions on Muscular Adaptations in Trained Males: Is There a Dose-Response Effect? https://pubmed.ncbi.nlm.nih.gov/37796222/ 19:55 Measurement methods and errors Barsuhn 2025 Training volume increases or maintenance based on previous volume: the effects on muscular adaptations in trained males https://pubmed.ncbi.nlm.nih.gov/39665246/ 26:00 The participant experience in high volume research and oedema 41:40 Criticisms of research methods 48:29 The applications of Eduardo's research 59:12 Trained and untrained participants and future research de Souza 2007 Acute effect of two aerobic exercise modes on maximum strength and strength endurancehttps://pubmed.ncbi.nlm.nih.gov/18076237/ 1:09:46 The aspects of future research which excites Eduardo (and a sneak peak into some sleep research) 1:21:45 Closing out and where to find Dr Eduardo de Souza Instagram @dr.desouzaeo https://www.instagram.com/dr.desouzaeo/?hl=en