A great day for science, a bad day for Covid-19. As the first Pfizer vaccines are given to patients in the UK, the Oxford-AstraZeneca vaccine publishes its data. Adam and Fergus chat to virologist Dr Elisabetta Groppelli about how the rollout might go - and learn some Italian while they're at it.

Jenny Hill has the latest from the prosecutors in Berlin trying to build a case against the suspect in the case of Madeleine McCann. And in honour of William Shakespeare, whose namesake got the vaccine today, we've rewritten one of his great monologues for the Covid age.

Studio director: Emma Crowe Producers: Rick Kelsey, Ben Weisz, Alix Pickles Editor: Dino Sofos