1) Human herpes 6 virus encephalitis and 2) Topic of the month: Stroke trials. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Joanna Jen interviews Dr. Mina Bhanushali and Sarah Kranick about their paper on human herpes 6 virus encephalitis and stem cell transplantation. Dr. Adam Numis is reading our e-Pearl of the week about ictal syncope. In the next part of the podcast Dr. Brett Kissela interviews Dr. Clay Johnston about CHANCE trial. All the participants have disclosures.Dr. Jen serves as an Associate Editor of Frontiers in Neuro-otology and Section Editor of Experimental Brain Research and receives research support from the FDA.Ms. Kranick is a staff member of the National Institute of Health.Dr. Bhanushali Is an employee of the National Institute of Health.Dr. Numis serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Kissela serves on scientific advisory board for Allergan, Inc.; has received funding for travel and speaker honoraria from Allergan, Inc.; has received research support from the NIH, will receive compensation from Reata Pharmaceuticals, Inc. for serving on the Event Adjudication Committee for the BEACON study, which they are sponsoring. and provides medico-legal reviews.Dr. Johnston serves as Co-Editor-in-Chief of Journal Watch Neurology; serves as Vice Editor of Annals of Neurology; is co-holder of patent on the RNA panel to identify TIA and risk stratify; Stryker Neurovascular, Boston Scientific, Kaiser-Permanente, NCRR/NCATS, CTSA, AHA/ASA, Bugher Award and the NIH and provided expert testimony in legal proceedings for GlaxoSmithKline.