Warning: That Coronavirus News You’re Reading Could Be All Wrong
From the start of this pandemic, science news has unfolded at a dizzying pace and crushing volume. Scientific research, which usually creeps along in the background until publication day and then pops up to say something worthy, is suddenly making breathtaking international news every few days.
The speed of science research has gone into overdrive and the media horde is hungry for answers. Science is meant to be a slow process of asking questions, then submitting the answers to the kind of vigorous probing ordinary people devote considerable energy to avoiding. After that is when the media report the answers—vetted! peer reviewed! confident!—usually with caveats attached: Areas where questions yet unasked are lingering to be sought after.
But now, studies on COVID-19 therapies and possible therapies and could-be-someday-down-the-road-if-it-proves-out-in-mice-first-therapies make screaming headlines before the studies are vetted to assess their merits or limitations. As a result, the public has heard some contradictory and confusing results, and some claims that are flat-out wrong.
KQED’s Tara Siler spoke with science reporter Danielle Venton about this problem and how to understand the science being reported these days. (Edited for length and clarity.)
Why are people hearing so much science that’s not ready for prime-time?
Danielle Venton: We're at a time where there’s this brand new problem, a brand new virus. There are so many unanswered questions. There's a huge need for research and a real desire to get it out quickly. Now, what is also true is that science can be a messy process and things aren't always correct. Science has a way of correcting itself, but unfortunately, right now, that process is happening in public.
What do you mean by messy process?
So many of the normal safeguards have been glossed over in this desire to get findings out quickly. Dr. Irving Steinberg is a professor of clinical pharmacy and pediatrics at USC. He's been talking and writing about this issue a lot, and he uses the analogy of working in a sausage factory where production suddenly had to be doubled because people were so hungry:
“You can imagine that there might be some problems that would arise in the back room where science is adjudicated—whether it's in the lab or whether it's in the editorial processes—where the sausage is made.
What the public is seeing is some of the spilled sausage out of the casing. You've got this sort of spillage of raw sausage. You know it's a food product, but you don't know what to do with it at that point. It's on the floor. It's dirty. I can't really put it on the grill. Maybe I can put it into a cast iron pan? We've left to the public too many things to figure out.”
What could happen here is that the public may begin to doubt the results. And the danger here is that the public may begin to doubt science. Right now, we are in need of good science and for the public to trust it.
What are some of the big failures in this pandemic, the so-called sausage spillage?
Early in March, some researchers raised concerns in a letter—not a reviewed study—that ibuprofen could worsen COVID-19 symptoms. It wasn’t based on experimental data, it was a theoretical concern based on how ibuprofen works in cells. Three days later, the French health minister tweeted a message saying to avoid ibuprofen. The World Health Organization did the same thing and then reversed itself a day later. More scientists weighed in, and now it’s thought that it’s fine to take ibuprofen. The original worries were based on an incomplete understanding.
A famous example is hydroxychloroquine, which was touted in public as a possible treatment for COVID-19 in an early study. The study was poorly designed and later retracted, but we saw some politicians, notably the president, seize on this and just shoot from the hip.
Demand surged for the drug, so that some patients who need it for conditions like lupus and rhe...
The speed of science research has gone into overdrive and the media horde is hungry for answers. Science is meant to be a slow process of asking questions, then submitting the answers to the kind of vigorous probing ordinary people devote considerable energy to avoiding. After that is when the media report the answers—vetted! peer reviewed! confident!—usually with caveats attached: Areas where questions yet unasked are lingering to be sought after.
But now, studies on COVID-19 therapies and possible therapies and could-be-someday-down-the-road-if-it-proves-out-in-mice-first-therapies make screaming headlines before the studies are vetted to assess their merits or limitations. As a result, the public has heard some contradictory and confusing results, and some claims that are flat-out wrong.
KQED’s Tara Siler spoke with science reporter Danielle Venton about this problem and how to understand the science being reported these days. (Edited for length and clarity.)
Why are people hearing so much science that’s not ready for prime-time?
Danielle Venton: We're at a time where there’s this brand new problem, a brand new virus. There are so many unanswered questions. There's a huge need for research and a real desire to get it out quickly. Now, what is also true is that science can be a messy process and things aren't always correct. Science has a way of correcting itself, but unfortunately, right now, that process is happening in public.
What do you mean by messy process?
So many of the normal safeguards have been glossed over in this desire to get findings out quickly. Dr. Irving Steinberg is a professor of clinical pharmacy and pediatrics at USC. He's been talking and writing about this issue a lot, and he uses the analogy of working in a sausage factory where production suddenly had to be doubled because people were so hungry:
“You can imagine that there might be some problems that would arise in the back room where science is adjudicated—whether it's in the lab or whether it's in the editorial processes—where the sausage is made.
What the public is seeing is some of the spilled sausage out of the casing. You've got this sort of spillage of raw sausage. You know it's a food product, but you don't know what to do with it at that point. It's on the floor. It's dirty. I can't really put it on the grill. Maybe I can put it into a cast iron pan? We've left to the public too many things to figure out.”
What could happen here is that the public may begin to doubt the results. And the danger here is that the public may begin to doubt science. Right now, we are in need of good science and for the public to trust it.
What are some of the big failures in this pandemic, the so-called sausage spillage?
Early in March, some researchers raised concerns in a letter—not a reviewed study—that ibuprofen could worsen COVID-19 symptoms. It wasn’t based on experimental data, it was a theoretical concern based on how ibuprofen works in cells. Three days later, the French health minister tweeted a message saying to avoid ibuprofen. The World Health Organization did the same thing and then reversed itself a day later. More scientists weighed in, and now it’s thought that it’s fine to take ibuprofen. The original worries were based on an incomplete understanding.
A famous example is hydroxychloroquine, which was touted in public as a possible treatment for COVID-19 in an early study. The study was poorly designed and later retracted, but we saw some politicians, notably the president, seize on this and just shoot from the hip.
Demand surged for the drug, so that some patients who need it for conditions like lupus and rhe...
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