Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in hemostasis. 

In today episode, our expert Pierre Bourgeat, will discuss about the Prothrombin time reagent characteristics with a specific focus on the ISI and the type of activators.  

As usual, don’t forget to send any question you may have to Ask@stago.com, we will be glad to answer to it.  

 

To learn more:

• Listen to our podcast about MNPT determination: #7 How to determine the mean normal prothrombin time 
• View the Webinar of Ian Jenning on stagowebinar.com  

 

Literature:

• Lusher, J. Screening and diagnosis of coagulation disorders. Am. J. Obstet. Gynecol. 1986; 175:778-783  
• Riley, R., Rowe, D., & Fisher, L. Clinical utilization of the international normalized ratio (INR). J. Clin. Lab. Anal. 2000; 14:101-114  
• WHO Technical Report Series, No. 610, 1977 
• Ian Jennings, PT/INR measurement for the management of VKA therapy, Stagowebinar.com, 3 October 2017 
• WHO Technical Report Series, No. 979, 2013 
• CLSI One-stage Prothrombin Time (PT) test and Activated Partial Thromboplastin Time (APTT) test; Approved guideline - second edition. CLSI document H47-A2 Wayne, PA: Clinical and Laboratory Standard Institute, 2008 
• Smith SA, Comp PC, Morrissey JH. Traces of factor VIIa modulate thromboplastin sensitivity to factors V, VII, X, and prothrombin. J Thromb Haemost. 2006;4(7):1553-1558. 

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.