1) Reduced trigeminovascular cyclicity in patients with menstrually-related migraine and 2) Topic of the month: Myelopathy due to systemic disease. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Andy Southerland interviews Dr. Antoinette Maassen van den Brink about her paper on reduced trigeminovascular cyclicity in patients with menstrually-related migraine. Dr. Sarah Wesley is reading our e-Pearl of the week about tauopathies. In the next part of the podcast Dr. Ted Burns interviews Dr. Steven L. Lewis about the topic of myelopathy due to systemic disease: infections. The participants had nothing to disclose except Drs. Southerland, Maassen van den Brink, Wesley, Burns and Lewis.Dr. Southerland serves as Podcast Deputy Editor for Neurology®; serves as Clinical Research Advisor for Totier Technologies, Inc.Dr. Maassen van den Brink received support for congress visits from Menarini Group; receives research support from Netherlands Organization for Scientific Research, Dutch Brain Foundation, Netherlands Heart Foundation, MAP Pharmaceuticals, Inc. and Allergan, Inc.Dr. Wesley serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with CSL Behring and Alexion Pharmaceuticals, Inc.Dr. Lewis serves as CME Section Co-Editor for Neurology® and as Editor in Chief for Continuum: Lifelong Learning in Neurology®; received royalties for book authorship and editorship from the publishers Wolters Kluwer and Wiley- Blackwell.