He came from a noble family, and was appointed military Governor of Alexandria and Egypt by the Emperor Constantine the Great. Some years later, the Emperor Julian the Apostate strove to restore pagan idolatry as the official religion of the Empire. He also entered into a war with Persia, and established Antioch as his headquarters for pursuing the war. In Alexandria, Artemius received an order to come to Antioch with the military forces under his command. Artemius reported to the apostate Emperor just in time to see him ordering the cruel execution of two pious Christians, Eugenius and Macarius. Fearlessly, St Artemius immediately denounced the Emperor, telling him to his face that his anti-Christian policy was of demonic origin. The enraged Emperor instantly had Artemius stripped of all official rank and thrown into prison. The following day, he had Artemius brought before him and promised him high Imperial office if he would only renounce Christ and worship the idols. When Artemius forcefully refused to do this, he was publicly tortured to death. A pious noblewoman secretly recovered the Saint's relics and took them to Constantinople, where they were venerated and wrought many miracles for several centuries.