This Podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Interim Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Russell Swerdlow interview Dr. Charles Hall about his paper on how cognitive activities delay onset of memory decline. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about paraspinal myotonic discharges in acid maltase deficiency. The podcast concludes where Dr. Winn Cashion interviews Mr. Azhar Nizam for the Lesson of the Week segment about fixed effects and random effects. The participants had nothing to disclose except for Drs. Hall, Cashion and Mr. Nizam. Dr. Hall serves on the editorial board of The Open Neurology Journal; has received honoraria for serving on peer review panels for the National Cancer Institute, the Breast Cancer Research Program, Congressionally Directed Medical Research Programs, the U.S. Army Department of Defense, the National Institute of Child Health and Human Development, and the NIA; has received salary support from the NIH [P01 AG03949 (Core Leader), P01 AG027734 (Biostatistician), UL1-RR025750-01 (Biostatistician), K30 HL 04110 (Biostatistician), P30 CA13330-35 (Biostatistician), R01 AG017854 , National Alzheimer's Coordinating Center project 2008-01 (Biostatistician), P30 CA13330-33 (Biostatistician), the U. S. Department of Defense grant BC043301 (Biostatistician), the US National Institute of Occupational Safety and Health grant U1O-OH008242 (Biostatistician)]; receives research support from the Breast Cancer Research Foundation, the American Cancer Society, and the NIH [5R01HL070785-05 (Consultant) and 5R01AG022092-05 (Consultant)]; and is a member of the American Statistical Association Media Experts List. Dr. Cashion received academic sponsorship from the Emory University MD/PhD Program. Mr. Nizam received royalties from Duxbury/Cengage for applied regression analysis and other multivariable methods in 2007; is a consultant/instructor for SAS Institute (2001 to present); has received research support from the NIH completed support [0000655466 (Principal Investigator), 2000009946 (Principal Investigator), 8311-97649-5 (Co-investigator), 1U01GM070749 (Co-Investigator), NIH ongoing support [5 R01 MH066767-06 (Biostatistician), MUSC08-041 (Biostatistician), and 4 U10 EY013287-06 (Biostatistician).