Drew opens the show welcoming guest Nikki Glaser whom he is a huge fan of and explains to Nikki how he became aware of her by way of Nikki's good friend Amy Schumer. The pair then get into Nikki's early life and her struggles with eating disorders and the resulting therapy. After Nikki tells Drew about her upcoming Comedy Central show they turn to the phones and talk a caller who is photoshopping her Tinder photos and another who wants to know if daily drinking can be normal for some.