Charles Semba, MD, is one of the more recognized and accomplished figures in development of new ophthalmology treatments. He has played integral roles in the development of Lucentis, Xiidra, and more recently Forsight IV’s drug delivery technology. Now the chief medical officer at Graybug Vision, Dr. Semba is working to develop a technology that could significantly reduce the number of injections needed to deliver drugs to the back and front of the eye. But how did Dr. Semba, who had been a world renowned vascular specialist, run out such a string of successes in ophthalmology? And what is the biggest regret of his accomplished career?