Tier 3 rules will be imposed on Greater Manchester from Friday, the prime minister has announced. Adam is joined by the BBC’s Vicki Young and Kevin Fitzpatrick to discuss the day's events. And Professor Peter Openshaw, from Imperial College London, explains why the UK is pushing ahead to be the first country to carry out “human challenge” studies where up to 90 healthy people will be deliberately exposed to Covid-19.

Studio Director: Emma Crowe Producers: Frankie Tobi, Ben Weisz, Jo Deahl Assistant Editor: Sam Bonham Editor: Dino Sofos