Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret
Bret speaks with Alexandros Marinos, who has analyzed the TOGETHER trial, which aims to identify effective repurposed therapies to prevent the disease progression of COVID-19.
Alexandros is the Founder/CEO of http://balena.io & aspiring practical philosopher. Find him on:
https://twitter.com/alexandrosm
https://doyourownresearch.substack.com/
Mentioned in this episode:
https://www.togethertrial.com/
https://doyourownresearch.substack.com/p/the-problem-with-the-together-trial
*****
Find Bret Weinstein on Twitter: @BretWeinstein, and on Patreon.
https://www.patreon.com/bretweinstein
Please subscribe to this channel for more long form content like this, and subscribe to the clips channel @DarkHorse Podcast Clips for short clips of all our podcasts:
https://www.youtube.com/channel/UCAWCKUrmvK5F_ynBY_CMlIA
All removed videos can be found on Spotify Video and Odysee: https://open.spotify.com/show/57R7dOcs60jUfOnuNG0J1R
https://odysee.com/@BretWeinstein:f
Check out the DHP store! Epic tabby, digital book burning, saddle up the dire wolves, and more: http://www.store.darkhorsepodcast.org
Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.
*****
Sign up for the Spectator at: https://spectatorworld.com/specialoffer/
Use code: DARKHORSE
Farrow SkinFood is lard-based skincare that nourishes the skin without preservatives or added chemicals.
Go to http://farrow.life/darkhorse for 20% off your first purchase; additional 15% off with a recurring subscription.
*****
Timestamps:
(00:00) Introduction
(03:11) Better Skeptics project – analyzing COVID podcasts
(08:12) TOGETHER trial and its timeline
(15:35) Ads
(19:08) Dosage & initial TOGETHER trial design
(25:29) Confusing paper and placebo group dropout?
(31:23) IVM dose too low and new protocol
(35:04) Trial recruitment over time and key 10-week period
(43:42) Systemic errors
(51:33) Placebo arm from earlier period?
(57:11) Trial data not being released
(01:02:27) Exclusion criteria flipped
(01:06:38) Hypothesis on algorithm rebalancing arms
(01:13:35) Allocation to Fluvoxamine arm
(01:17:12) TOGETHER trial authors believe IVM has an effect
(01:20:15) Credible intervals and Bayesian statistics
(01:25:55) Will we ever get the full story?
(01:30:28) Dosing and weight limit
(01:34:52) Background use of IVM in Brazil
(01:47:19) “Independent” committee monitoring trial
(01:54:29) Cavallo study and inconsistency in response
(01:57:41) Press releases and cold confusion
(02:09:27) Wrap up