1) Neuromyelitis optica and 2) Topic of the month: Historical interviews. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Pearce Korb interviews Drs. Claudia Lucchinetti and Bogdan Popescu about their paper on neuromyelitis optica unique area postrema lesions. In the next segment, Dr. Stacey Clardy is reading our e-Pearl of the week about striatal hand and foot. In the next part of the podcast Dr. Farrah Mateen interviews Dr. Bud Rowland as part of our month of historical interviews. Over the subsequent three weeks, Dr. Mateen will interview Drs. C. Miller Fisher, Peter Dyck and Jerome Posner. The participants had nothing to disclose except Drs. Lucchinetti, Clardy, Mateen and Rowland.Dr. Lucchinetti may accrue revenue for a patent re: aquaporin-4 associated antibodies for diagnosis of neuromyelitis optica; receives royalties from the publication of Blue Books of Neurology: Multiple Sclerosis 3 (Saunders Elsevier, 2010); and receives research support from the NIH, the Guthy Jackson Charitable Foundation (PI), and the National MS Society.Dr. Clardy serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Mateen served on the editorial team for the Neurology® Resident and Fellow Section and is supported by the 2010 Practice Research Grant from the American Academy of Neurology.Dr. Rowland serves as Ombudsman for Neurology; receives royalties from the publication of Merritt's Neurology (Lippincott Williams & Wilkins, 2005); and served as Editor-in-Chief of Neurology Today.