Drugs are another means toward this end. Some are illegal; some are stigmatized; some are dangerous—though, perversely, these sets only partially intersect. Some drugs of extraordinary power and utility, such as psilocybin (the active compound in “magic mushrooms”) and lysergic acid diethylamide (LSD), pose no apparent risk of addiction and are physically well-tolerated, and yet one can still be sent to prison for their use—whereas drugs such as tobacco and alcohol, which have ruined countless lives, are enjoyed ad libitum in almost every society on earth. There are other points on this continuum: MDMA, or Ecstasy, has remarkable therapeutic potential, but it is also susceptible to abuse, and some evidence suggests that it can be neurotoxic.[1] One of the great responsibilities we have as a society is to educate ourselves, along with the next generation, about which substances are worth ingesting and for what purpose and which are not. The problem, however, is that we refer to all biologically active compounds by a single term, drugs, making it nearly impossible to have an intelligent discussion about the psychological, medical, ethical, and legal issues surrounding their use. The poverty of our language has been only slightly eased by the introduction of the term psychedelics to differentiate certain visionary compounds, which can produce extraordinary insights, from narcotics and other classic agents of stupefaction and abuse. However, we should not be too quick to feel nostalgia for the counterculture of the 1960s. Yes, crucial breakthroughs were made, socially and psychologically, and drugs were central to the process, but one need only read accounts of the time, such as Joan Didion’s Slouching Towards Bethlehem, to see the problem with a society bent upon rapture at any cost. For every insight of lasting value produced by drugs, there was an army of zombies with flowers in their hair shuffling toward failure and regret. Turning on, tuning in, and dropping out is wise, or even benign, only if you can then drop into a mode of life that makes ethical and material sense and doesn’t leave your children wandering in traffic. Drug abuse and addiction are real problems, of course, the remedy for which is education and medical treatment, not incarceration. In fact, the most abused drugs in the United States now appear to be oxycodone and other prescription painkillers. Should these medicines be made illegal? Of course not. But people need to be informed about their hazards, and addicts need treatment. And all drugs—including alcohol, cigarettes, and aspirin—must be kept out of the hands of children. I discuss issues of drug policy in some detail in my first book, The End of Faith, and my thinking on the subject has not changed. The “war on drugs” has been lost and should never have been waged. I can think of no right more fundamental than the right to peacefully steward the contents of one’s own consciousness. The fact that we pointlessly ruin the lives of nonviolent drug users by incarcerating them, at enormous expense, constitutes one of the great moral failures of our time. (And the fact that we make room for them in our prisons by paroling murderers, rapists, and child molesters makes one wonder whether civilization isn’t simply doomed.) I have two daughters who will one day take drugs. Of course, I will do everything in my power to see that they choose their drugs wisely, but a life lived entirely without drugs is neither foreseeable nor, I think, desirable. I hope they someday enjoy a morning cup of tea or coffee as much as I do. If they drink alcohol as adults, as they probably will, I will encourage them to do it safely. If they choose to smoke marijuana, I will urge moderation.[2]  Tobacco should be shunned, and I will do everything within the bounds of decent parenting to steer them away from it. Needless to say, if I knew that either of my daughters would eventually develop a fondness for methamphetamine or crack cocaine, I might never sleep again. But if they don’t try a psychedelic like psilocybin or LSD at least once in their adult lives, I will wonder whether they had missed one of the most important rites of passage a human being can experience. This is not to say that everyone should take psychedelics. As I will make clear below, these drugs pose certain dangers. Undoubtedly, some people cannot afford to give the anchor of sanity even the slightest tug. It has been many years since I took psychedelics myself, and my abstinence is born of a healthy respect for the risks involved. However, there was a period in my early twenties when I found psilocybin and LSD to be indispensable tools, and some of the most important hours of my life were spent under their influence. Without them, I might never have discovered that there was an inner landscape of mind worth exploring. There is no getting around the role of luck here. If you are lucky, and you take the right drug, you will know what it is to be enlightened (or to be close enough to persuade you that enlightenment is possible). If you are unlucky, you will know what it is to be clinically insane. While I do not recommend the latter experience, it does increase one’s respect for the tenuous condition of sanity, as well as one’s compassion for people who suffer from mental illness. Human beings have ingested plant-based psychedelics for millennia, but scientific research on these compounds did not begin until the 1950s. By 1965, a thousand studies had been published, primarily on psilocybin and LSD, many of which attested to the usefulness of psychedelics in the treatment of clinical depression, obsessive-compulsive disorder, alcohol addiction, and the pain and anxiety associated with terminal cancer. Within a few years, however, this entire field of research was abolished in an effort to stem the spread of these drugs among the public. After a hiatus that lasted an entire generation, scientific research on the pharmacology and therapeutic value of psychedelics has quietly resumed. Psychedelics such as psilocybin, LSD, DMT, and mescaline all powerfully alter cognition, perception, and mood. Most seem to exert their influence through the serotonin system in the brain, primarily by binding to 5-HT2A receptors (though several have affinity for other receptors as well), leading to increased activity in the prefrontal cortex (PFC). Although the PFC in turn modulates subcortical dopamine production—and certain of these compounds, such as LSD, bind directly to dopamine receptors—the effect of psychedelics seems to take place largely outside dopamine pathways, which could explain why these drugs are not habit-forming. The efficacy of psychedelics might seem to establish the material basis of mental and spiritual life beyond any doubt, for the introduction of these substances into the brain is the obvious cause of any numinous apocalypse that follows. It is possible, however, if not actually plausible, to seize this evidence from the other end and argue, as Aldous Huxley did in his classic The Doors of Perception, that the primary function of the brain may be eliminative: Its purpose may be to prevent a transpersonal dimension of mind from flooding consciousness, thereby allowing apes like ourselves to make their way in the world without being dazzled at every step by visionary phenomena that are irrelevant to their physical survival. Huxley thought of the brain as a kind of “reducing valve” for “Mind at Large.” In fact, the idea that the brain is a filter rather than the origin of mind goes back at least as far as Henri Bergson and William James. In Huxley’s view, this would explain the efficacy of psychedelics: They may simply be a material means of opening the tap. Huxley was operating under the assumption that psychedelics decrease brain activity. Some recent data have lent support to this view; for instance, a neuroimaging study of psilocybin suggests that the drug primarily reduces activity in the anterior cingulate cortex, a region involved in a wide variety of tasks related to self-monitoring. However, other studies have found that psychedelics increase activity throughout the brain. Whatever the case, the action of these drugs does not rule out dualism, or the existence of realms of mind beyond the brain—but then, nothing does. That is one of the problems with views of this kind: They appear to be unfalsifiable.[3] We have reason to be skeptical of the brain-as-barrier thesis. If the brain were merely a filter on the mind, damaging it should increase cognition. In fact, strategically damaging the brain should be the most reliable method of spiritual practice available to anyone. In almost every case, loss of brain should yield more mind. But that is not how the mind works. Some people try to get around this by suggesting that the brain may function more like a radio, a receiver of conscious states rather than a barrier to them. At first glance, this would appear to account for the deleterious effects of neurological injury and disease, for if one smashes a radio with a hammer, it will no longer function properly. There is a problem with this metaphor, however. Those who employ it invariably forget that we are the music, not the radio. If the brain were nothing more than a receiver of conscious states, it should be impossible to diminish a person’s experience of the cosmos by damaging her brain. She might seem unconscious from the outside—like a broken radio—but, subjectively speaking, the music would play on. Specific reductions in brain activity might benefit people in certain ways, unmasking memories or abilities that are being actively inhibited by the regions in question. But there is no reason to think that the pervasive destruction of the central nervous system would leave the mind unaffected (much less improved). Medications that reduc