Premature Ovarian Insufficiency (POI) has replaced the previous term of “premature ovarian failure” or “premature menopause”. POI is a stressful and emotional taxing diagnosis for any woman, especially the adolescent and young patient. Other endocrinopathies may be present in patients with POI including thyroid abnormalities and adrenal insufficiency. In this session, we will review the last ACOG Committee Opinion on POI in adolescents and young women (CO 605).