This Podcast for the Neurology Journal begins and closes with Dr. John H. Noseworthy, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Guillermo Solorzano interview Drs. Peter Nigel Leigh and Ammar Al-Chalabi about their paper on ALS variants. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about Foix Chavany Marie syndrome. The podcast concludes where Dr. Michael Benatar interviews Dr. Rami Ibrahim for the Lesson of the Week segment. The participants had nothing to disclose.