She was born to a pious, noble and very wealthy family in Thessalonica. When both her parents died while she was an adolescent, Anysia consecrated herself to Christ, the heavenly Bridegroom. She cast off all her jewels and fine clothing, dressing herself as a commoner. She freed all her many slaves, giving each of them a generous sum of money to establish themselves. She gave away all of her inheritance, which included large estates. Thenceforth she spent her days visiting the sick, helping widows and orphans, and, especially, aiding Christians suffering under persecution. She would visit those in prison, bringing them food and water and tending their wounds. All the time not devoted to aiding the poor or oppressed she spent in prayer in a small cell. One of her prayers was that she, like those that she helped, would be granted the crown of martyrdom.
  One day, while she was walking to church, an imperial soldier accosted her and roughly questioned her. When she plainly declared herself a Christian, the soldier seized her and dragged her to a temple of the idols, where he commanded her to make sacrifice. In response, she only spat in his face. The enraged soldier drew his sword and thrust it into her side, slaying her. Some pious Christians took her body and buried it outside the city. When the persecutions had ended, a church was built in her honor at the place of her burial.