1) APOE-e4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline 2) e-Pearl topic: Ocular neuromyotonia3) Topic of the month: Neurology Today story about Neurology Today story about new Center for Disease Control guidelines on prescribing opioids (Part 2)This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Burns interviews Prof. Martha Morris about her paper on APOE-e4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Dr. Adam Numis is reading our e-Pearl of the week about ocular neuromyotonia. Dr. Ted Burns interviews Dr. Gary Franklin about a Neurology Today story on the topic of the new Center for Disease Control guidelines on prescribing opioids (Part 2).DISCLOSURES: Dr. Jeff Burns serves on the editorial board for Journal of Alzheimer's Disease; receives royalties for the publications of Early diagnosis and treatment of mild cognitive impairment and Dementia: An atlas of investigation and diagnosis; is a consultant for PRA International and receives research support from the NIH, Alzheimer's Drug Discovery Foundation, Elan, Janssen Pharmaceuticals Inc., Wyeth, Pfizer Inc, Novartis Pharmaceuticals Ltd, Danone, Avid Radiopharmaceuticals, Merck Serono and for clinical trials.Prof. Morris is a consultant for Neurotrack; serves on the scientific advisory board for the University of Chicago; received funding for travel from the University of California; receives research support from the Abbott Fund and the NIH.Dr. Numis serves on the editorial team for the Neurology® Resident and Fellow Section.Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Franklin serves as an editorial board member of Neuroepidemiology; serves on the Levels of Evidence Team for Neurology®; is a consultant for the California State Compensation Insurance Fund; receives research support from the Centers for Disease Control and Prevention.