Pediatric cancer is the leading cause of death by disease past infancy among children in the United States and Europe. Despite prevailing increases in overall survival rates, it continues to be one of the most challenging diseases to treat. This podcast will discuss the latest advancements in pediatric cancer research and how they can lead to newer, faster, and better treatments for children and adolescents with cancer. This podcast was produced using excerpts from the 2018 Sohn Conference: Accelerating Translation of Pediatric Cancer Research (www.nyas.org/Sohn2018) on this topic held in partnership between the Sohn Conference Foundation (www.sohnconference.org) and the New York Academy of Sciences.