She was sought as a bride by many because of her exceptional beauty and wisdom as well as her noble birth. She was betrothed at a young age, and when her betrothed died, she refused to consider any more suitors, saying that since her betrothed was alive in Christ, it was not right for her to turn to another. Instead she turned to a life of virginity, ascetic struggle and prayer. She greatly influenced her younger brothers, turning them from worldly things to monastic life. She established a monastery and, with her mother Emilia, became a nun. She reposed in peace in 379.
Her brother St Gregory of Nyssa held her in special honor. He was present at her death and gave a moving oration at her funeral. He describes how, in her last moments, she prayed thus to God: 'Thou, O Lord, givest rest to our bodies in the sleep of death for a little time, then Thou wilt waken them again with the Last Trumpet. Forgive me, and grant that, when my soul is parted from my body, it may be presented before