**Trigger Warning**

Naman Julka-Anderson and Jo McNamara catch up with Dr. Arjun Sahgal to discuss his career, and the uses of radiosurgery for brain metastasis.

To use this podcast as CPD, look at these reflection points: 

1) read about the symptoms of a brain tumour: https://www.thebraintumourcharity.org/brain-tumour-signs-symptoms/adult-brain-tumour-symptoms/

2) reflect on the benefits of radiosurgery for people diagnosed with brain metastasis.

3) consider the impact of reduced access to radiosurgery could have on a a person living with beyond cancer and their loved ones / carers.

4) watch this video on the Elekta Gamma Knife Radiosurgery: https://www.youtube.com/watch?v=pxikNfTbtzw 

Complete this form for your accredited digital badge: https://bit.ly/3GbtR1X.

Links from podcast:

Elekta: https://www.elekta.com/

Elekta Gamma Knife Radiosurgery: https://www.elekta.com/patients/gamma-knife-treatment/

Leksell Gamma Knife Lightening: https://www.elekta.com/products/stereotactic-radiosurgery/leksell-gamma-knife-lightning/

The National Centre for Stereotactic Radiosurgery: https://www.gammaknife.org.uk/

The National Centre for Stereotactic Radiosurgery Videos on how to prepare for treatment: https://www.gammaknife.org.uk/treatment/videos

Brain Tumour Charity: https://www.thebraintumourcharity.org/brain-tumour-signs-symptoms/adult-brain-tumour-symptoms/

Brain Tumours Macmillan Cancer Support: https://www.macmillan.org.uk/cancer-information-and-support/brain-tumour

Therapeutic Role of Gamma Knife Stereotactic Radiosurgery in Neuro-Oncology (2020): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023953/

Characterization and commissioning of a Leksell Gamma Knife ICON system for framed and frameless stereotactic radiosurgery (2022): https://pubmed.ncbi.nlm.nih.gov/35064749/ Concurrent Olaparib and Radiation Therapy in Older Patients With Newly Diagnosed Glioblastoma: The Phase 1 Dose-Escalation PARADIGM Trial (2024): https://www.sciencedirect.com/science/article/pii/S0360301624000154?via%3Dihub 

FINAL RESULTS OF THE MGMT UNMETHYLATED ARM OF PARADIGM-2: A PHASE I STUDY OF OLAPARIB AND RADIOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GBM) (2023): https://academic.oup.com/neuro-oncology/article-abstract/25/Supplement_2/ii20/7264478?redirectedFrom=fulltext&login=true 

Results of the OPARATIC trial: A phase I dose escalation study of olaparib in combination with temozolomide (TMZ) in patients with relapsed glioblastoma (GBM) (2017): https://ascopubs.org/doi/10.1200/JCO.2017.35.15_suppl.2022 

Non-Cancerous Conditions Links:

The National Centre for Stereotactic Radiosurgery Other Conditions Treated: https://www.gammaknife.org.uk/conditions-treated/conditions

Elekta case stud on bilateral thalamotomy with Leksell Gamma Knife for Essential Tremor: https://www.elekta.com/medical-affairs/case-studies/case-study-bilateral-thalamotomy-with-leksell-gamma-knife-for-essential-tremor/

Gamma Knife radiosurgery for cerebral arteriovenous malformations: a systematic review and meta-analysis (2022): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160151/

Gamma Knife Radiosurgery For Brain Vascular Malformations: Current Evidence And Future Tasks (2019): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874113/ 

Gamma Knife Radiosurgery for Trigeminal Neuralgia : Review and Update (2022): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452385/

Arjun’s Research:

Hypofractionated stereotactic radiosurgery(HSRS) as a salvage treatment for brain metastases failing prior stereotactic radiosurgery(SRS).

Yan M, Lee M, Myrehaug S, Tseng CL, Detsky J, Chen H, Das S, Yeboah C, Lipsman N, Costa LD, Holden L, Heyn C, Maralani P, Ruschin M, Sahgal A, Soliman H. J Neurooncol. 2023 Mar;162(1):119-128. doi: 10.1007/s11060-023-04265-y. Epub 2023 Mar 13.

Gamma knife icon based hypofractionated stereotactic radiosurgery(GKI-HSRS) for brain metastases: impact of dose and volume.

Yan M, Holden L, Wang M, Soliman H, Myrehaug S, Tseng CL, Detsky J, Ruschin M, Tjong M, Atenafu EG, Das S, Lipsman N, Heyn C, Sahgal A, Husain Z. J Neurooncol. 2022 Sep;159(3):705-712. doi: 10.1007/s11060-022-04115-3. Epub 2022 Aug 24.

Conventionally fully fractionated Gamma Knife Icon re-irradiation of primary recurrent intracranial tumors: the first report indicating feasibility and safety.

Yan M, Holden L, Detsky J, Tseng CL, Soliman H, Myrehaug S, Husain Z, Das S, Yeboah C, Lipsman N, Ruschin M, Sahgal A.

Precision Radiation for Brain Metastases With a Focus on Hypofractionated Stereotactic Radiosurgery.

Shiue K, Sahgal A, Lo SS. Semin Radiat Oncol. 2023 Apr;33(2):114-128. doi: 10.1016/j.semradonc.2023.01.004.

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