Biochemist Virginia Man-Yee Lee has spent a lifetime in the lab, figuring out what happens in the brains of people with neurodegenerative diseases. She’s made key discoveries about Parkinson's, ALS, and Alzheimer's.The secret to her success? Happiness. “If you're not happy, you don’t know what you’re capable of,” Lee says. Neurologist Ken Kosick reflects on the early days of Alzheimer’s research, and neurologist Alice S. Chen-Plotkin, a former postdoc in Virginia’s lab, gives us a fly-on-the-wall look at the unusual research partnership between Lee and her husband John Trojanowski.“The Leap” is a 10-episode audio series that profiles scientists willing to take big risks to push the boundaries of discovery. It premieres on Science Friday’s podcast feed every Monday until July 21. “The Leap” is a production of the Hypothesis Fund, brought to you in partnership with Science Friday.Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.