Willy welcomes Dr. Michael Roizen and Dr. Peter Linneman. Dr. Michael Roizen is the Chief Wellness Officer and Chair of the Wellness Institute at Cleveland Clinic. His books, RealAge and YOU: The Owner's Manual: An Insider's Guide to the Body that Will Make you Healthier and Younger, has been translated into more than 44 languages and became #1 in the NY Times Bestsellers list. Dr. Peter Linneman is the principal of Linneman Associates, KL, Realty, and American Land Fund. He is a highly sought-after speaker and author, with his quarterly research, The Linneman Letter, the most respected publication in real estate for the past 11 years. The podcast begins with Dr. Michael Roizen defining RealAge as "the actual age of your body as opposed to your calendar age." It is the most accurate predictor of cardiovascular and all-cause mortality. The critical factors to maintaining one's health and lowering one's RealAge are stress management (having a purpose and a posse), food choices (portion size and timing), physical activity, unforced errors, sleep and brain health, and supplements. He adds that creatine has been proven to decrease muscle mass loss for people over 65 and improves cognitive function. Around 18 supplements or small molecules have beneficial data. Dr. Peter Linneman takes over the conversation and emphasizes how much control we have over our destinies regardless of genetics. "We control 80% of our DNA settings," he says. This can be done through self-engineering. Dr. Roizen adds that exercise improves blood flow to the brain, prevents dementia, and turns on a new protein in your body that increases your hippocampal size. Whatever exercise you enjoy, as long as you stress a muscle, produces this protein. When comparing different types of exercises, Dr. Roizen says that some people benefit from cardio more than resistance training and vice versa. He adds that we should also consider jumping because it keeps our back disks lubricated, especially if you jump at times of the day when you lose mobility. He reminds everyone to consult a professional before doing it. He says that resistance training encourages muscles to be replaced with stronger ones the next day. Jumping also increases bone accretion and bone strength in one's hips and back. Dr. Roizen lists the five foods that increase aging: simple sugars, added syrups, simple carbohydrates, processed and red meats, and egg yolks. He recommends eating earlier because we become more insulin-resistant later in the day. People who avoid these foods and practice these portions sleep better, have more energy and are not hungry at night. Dr. Linneman gave up red meat in 1983. "Not only do you feel better, but you live better," he says. He discusses "staying healthy until the cavalry gets there." He also emphasizes how we cannot afford as a society not to reboot. The more we take care of ourselves, the more years are added to our lives, and the larger the increase in productivity. "Ten years is a 25% increase in your productive output in life," he says. Dr. Roizen explains how exercise can change the bacteria inside us. Studies have also shown that living healthy lives can knock out bodily mechanisms that don't attack cancer cells. Jim Allison's extensive work has produced KEYTRUDA, the medicine we use today to combat malignant melanoma, with a 63% cure rate. Internally, we can also produce killer T cells that can fight viruses. The strongest thing that knocks out our immune system is stress, so Dr. Roizen recommends doing exercises that don't stress you out, taking multivitamins, and having a dedicated group of friends.

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