Once taboo, anal sex has slowly been slipping into the mainstream. A recent study found that 37% of women reported having anal sex with the opposite sex in their lifetime, and over 60% reported providing oral sex. However, the CDC does not specifically mention routine screening of extragenital sites for STIs. In this podcast, we will review the most up-to-date data on extragenital infection and make the case for “routine“ screening of extragenital STIs.