Today, we’re unlocking the full potential of your brain—starting with Bryan Johnson’s Blueprint for longevity and brain optimization. 

We’re revisiting our conversation with Bryan, the creator of the Don’t Die movement (among many other things), to explore how his groundbreaking approach to brain health and biohacking is reshaping the future of longevity. 

First, we dive into Bryan’s mission to make brain monitoring as easy as tracking blood glucose, using his Blueprint protocol to measure and optimize cognitive performance for better health and wellness. 

Then, we tackle the deeper side of biohacking—longevity, societal reactions to living longer, and how to handle critics when you’re pushing the limits of human potential. 

Finally, Bryan shares his personal journey—investing $80M into brain science, building the Blueprint for optimal living, and discovering the power of community and lifelong friendships for a long, vibrant life. This episode will change the way you think about brain health and the future of humanity. 

Sponsors: 

• Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 
• Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. 

Resources: 

• Bryan Johnson’s Blueprint Protocol: https://blueprint.bryanjohnson.com/ 
• Bryan Johnson’s Don’t Die Movement: https://dontdie.bryanjohnson.com/ 
• Bryan Johnson’s Kernel: https://www.kernel.com/ 
• Bryan Johnson’s YouTube Channel: https://www.youtube.com/@bryanjohnson_ 
• Bryan Johnson’s Instagram: https://www.instagram.com/bryan_johnson_ 
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 
• Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books 
• Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ 
• Supplements by Dave Asprey: https://shopsuppgradelabs.com 
• Join The Human Upgrade Podcast Live – Upgrade Collective: https://www.ourupgradecollective.com 
• Own an Upgrade Labs: https://ownanupgradelabs.com 

Timestamps and Highlights: 

00:00 Introduction and Bold Claims 

00:39 Meet Bryan Johnson: The Neuroscience Pioneer 

01:23 Kernel: Revolutionizing Brain Measurement 

05:51 Biohacking and Longevity 

07:30 Facing Criticism and Staying Resilient 

16:06 Media Training Insights 

19:49 Personal Reflections and Relationships 

34:37 Exercise and Longevity 

44:46 Optimizing Brain-Body Interface 

45:25 Longevity Hacks and Driving Preferences 

45:48 Debating Olive Oil and Saturated Fats 

46:52 The Blueprint Approach to Health 

48:38 Testing and Metrics in Health 

52:22 Testosterone and Hormone Protocols 

56:27 Exploring Semen Retention 

01:00:44 Body Hair and Aesthetics 

01:04:26 Psychedelics and Consciousness 

01:08:32 Audience Q&A and Final Thoughts 

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