1) Reducing costs while enhancing quality of care in MS2) What's Trending: Interview with Lyell Jones about the topic of the Axon Registry and how it interfaces with practice and reimbursement this is part 2 with part 1 appearing last month 3) Topic of the month: Neurology Today story on the AAN Guideline published in Neurology on the topic of recurrent stroke with patent foramen ovaleThis podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Mark Keegan interviews Dr. Ilya Kister about his paper on the various approaches neurologists may contribute to cost containment while maintaining and enhancing the quality of MS care. Dr. Andy Southerland is interviewing Dr. Lyell Jones for our “What's Trending” feature of the week about the topic of the Axon Registry and how it interfaces with practice and reimbursement. This is part 2 with part 1 appearing last month. In the next part of the podcast Dr. Bryan Eckerle interviews Dr. Steven Messe about a Neurology Today story on the AAN Guideline published in Neurology on the topic of recurrent stroke with patent foramen ovale.DISCLOSURES: Dr. Keegan serves as an editorial board member of Multiple Sclerosis and Related Disorders; served as Chief Editor of eMedicine; receives royalties from the publication of the book: Common Pitfalls in Multiple Sclerosis and CNS Demyelinating Diseases: Case-Based Learning; is a consultant for Novartis, Bristol-Meyers Squibb and Bionest; receives research support from Terumo BCT.Dr. Kister serves on the MS Franchise Data Generation advisory board for Biogen Idec and advisory board for Genentech, Inc.; received a one-time consulting fee from Biogen Idec; received research support from Biogen-Idec, Merck Serono, Novartis, Genzyme Corporation; Guthy-Jackson Charitable Foundation and National Multiple Sclerosis Society.Dr. Southerland serves as Podcast Deputy Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: “Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;” and gave legal expert review. Dr. Messe received publishing royalties from UpToDate; received compensation from GlaxoSmithKline for consulting on protocol development for a trial of a neuroprotectant in high risk surgery; received research support from GlaxoSmithKline, Bayer Schering Pharma, WL Gore and the NIH.