On episode 706 of the 40+ Fitness, we’re diving deep into the world of GLP-1 agonist medications—those buzzy drugs you've likely seen in the headlines helping people tackle obesity and type 2 diabetes. Joining Coach Allan is David Knapp, a leading voice in the GLP-1 community and author of Decoding GLP1: A Guide for Friends and Family of Those on the Pen.
David opens up about his own weight loss journey, struggles with type 2 diabetes, and why traditional "eat less, move more" advice often isn’t enough. He demystifies the science behind GLP-1 medications, shares the fascinating history of their development (think lizard venom, not snake oils!), and breaks down the latest options and future innovations in this rapidly evolving space.
Whether you’re considering these medications, supporting a loved one who is, or just curious about the hype, this episode will give you clear, compassionate, and evidence-backed insights. Plus, you'll hear candid discussions about stigma, navigating the world of compounded versus branded medications, and practical advice on achieving lasting wellness—no matter where you’re starting from. Time Stamps:
05:32 Beyond "Calories In, Calories Out"
07:17 Struggles with Weight Loss Mismanagement
11:17 Yo-Yo Dieting to Diabetes
14:00 Insulin's Role in Weight Challenges
17:26 Incretin Hormones and DPP4 in Diabetes
20:16 Ozempic's Origins: Gila Monster Venom
24:06 Understanding Tirzepatide’s Brain Effects
28:51 Novel Peptides in Weight Management
29:54 Retatrutide's Role in Body Composition
36:26 GLP1 Drug Shortage and Compounding
40:07 Pharmacy Oversight and Safety Concerns
41:14 Sketchy Weight Loss Injections
46:29 Obesity Stigma and Personal Struggle
51:00 OnThePen.com: Medication News Hub